In Silico study of 3-D structural interactions and quantitative structural drug likeness of marketed Cox-2 inhibitors

In the field of molecular modeling, docking may be a method which predicts well-liked orientation any molecule to receptor make stable complex. Knowledge successively could also able predict strength association or binding affinity between two molecules using, for instance, scoring functions. Cyclooxygenase-2 (COX-2) inhibitors block cyclooxygenase-2 (COX-2), an enzyme that promotes inflammation. COX-2 converts prostaglandin via arachidonic acid, causing pain and inflammatory responses. They are mainly present in places inflammation responsible formation prostanoids (prostacyclins, prostaglandins thromboxane) as part response. used relieve raised from study, marketed COX-II subjected study drug likeness validate drugs show optimum energy score with bioactive score.